Conbercept is a Luggage genetically engineered homodimeric protein for the treatment of wet age-related macular degeneration (wet AMD) that functions by blocking VEGF-family proteins.Its huge, highly variable architecture makes characterization and development of a functional assay difficult.In this study, the primary structure, number of disulfide
Young adults in rural areas in many cases have limited educational opportunities.To obtain higher educational qualifications, rural youth often travel long distances.Therefore, many rural youths choose the “shorter” route and complete vocational training closer to home or drop out of their education prematurely.Against this background, this stu
We report a case of methotrexate (MTX)-induced stroke-like encephalopathy in an 18-year-old woman, with acute lymphoblastic leukemia, who developed LEGO Minions a sudden neurological deficit mimicking a cerebrovascular event.Bain MRI showed hyperintensities on diffusion-weighted-imaging (DWI) with matching apparent diffusion coefficient hypointensi
Collections Abstract In patients with relapsed or refractory neuroblastoma (NB), the limited efficacy of conventional chemotherapies necessitates the exploration of new treatment options.Previous studies have highlighted the anti-tumor properties of arsenic trioxide (ATO) in high-risk NB (HR-NB).This study aims to assess the effectiveness and safet